RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury

The retinoid acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR) have been implicated in the regulation of inflammatory reactions. Both receptor families contain ligand-activated transcription factors which form heterodimers with retinoid X receptors (RXR). We review data that imply RAR/RXR and PPAR/RXR pathways in physiological reactions after spinal cord injury. Experiments show how RAR signaling may improve axonal regeneration and modulate reactions of glia cells. While anti-inflammatory properties of PPAR are well documented in the periphery, their possible roles in the central nervous system have only recently become evident. Due to its anti-inflammatory function this transcription factor family promises to be a useful target after spinal cord or brain lesions

Проектирование автоматизированной системы управления резервуарного парка нефтяного месторождения

Объектом исследования является резервуарный парк нефтеперекачивающего месторождения. Цель работы – модернизация автоматизированной системы управления насосным агрегатом резервуарного парка нефтеперекачивающего месторождения с использованием ПЛК, на основе выбранной SCADA-системы. В данном проекте была разработана система контроля и управления технологическим процессом на базе промышленных контроллеров Yokogawa CENTUM CS, с применением SCADA-системы GENESIS32. Разработанная система может применяться в системах контроля, управления и сбора данных на различных промышленных предприятиях. Данная система позволит увеличить производительность, повысить точность и надежность измерений, сократить число аварий.The object of the study is the tank farm of an oil-pumping field. The purpose of the work is the modernization of the automated control system for the pump unit of the oil-storage reservoir reservoir using PLCs, based on the SCADA system chosen. In this project, a process control and management system was developed on the basis of industrial controllers Yokogawa CENTUM CS, using the SCADA system GENESIS32. The developed system can be used in monitoring, control and data collection systems at various industrial enterprises. This system will increase the productivity, improve the accuracy and reliability of measurements, reduce the number of accidents

Güvercin

Adolphe Belot'nun Sabah'ta yayımlanan Güvercin adlı romanının ilk ve son tefrikalar

Zur Frage der Integration qualitativer und quantitativer Forschung in der Psychologie: eine Einführung und ein Diskussionsbeitrag

"In dem erweiterten Editorial zum Schwerpunktteil „Die Integration qualitativer und quantitativer Forschung (IQQF) in der Psychologie“ werden zunächst fünf aktuelle, genuine IQQF-Konzeptionen vorgestellt und hinsichtlich ihrer Perspektiven auf Grenzen und Möglichkeiten von Integrationsdesigns verglichen. Hierbei wird ein besonderes Augenmerk auf die Frage gerichtet, welche dieser Designs für die Psychologie als eher unproblematisch und welche als besonders herausfordernd zu bewerten sind; als zu letzterer zugehörig wird die gleichrangige Integration von qualitativen und quantitativen Ergebnissen zu einer Forschungsfrage identifiziert. Speziell dazu wird ein Disposition-Sinn- Modell vorgeschlagen, anhand dessen sich zukünftige Entwicklungsmöglichkeiten von mixed methods in der Psychologie diskutieren lassen. Das Editorial schließt mit einer Übersicht der im Schwerpunktteil versammelten Beiträge, die als Beispiele für in der Psychologie gängigen IQQFVarianten stehen und Anregungen bieten für die weiterführende Methodenentwicklung in der psychologischen Forschung." (Autorenreferat)"This extended editorial introduces into the special issue on „The integration of qualitative and quantitative research (IQQR) in psychology” and also presents a genuine contribution to the debate. We begin with a brief description of five current methodological conceptions on IQQR provided in the literature and compare them concerning their specific perspectives on chances and limitations of mixed methods designs. Herein, we give our attention to the question of which of these designs may be easily adopted by psychological research and which, in contrast, may be particularly challenging. As a good example of the latter we identify designs in which qualitative and quantitative research findings are integrated in an approach that attaches equal value to both methodological strands. Specifically to this point, we then propose a Disposition-Meaning-Model which we use in order to discuss the chances of the future development of mixed methods in psychology. This editorial ends with a brief presentation of the papers contributing to this special issue and with the recommendation to make use of their thematic and methodological diversity for the further development of methods in psychological research." (author's abstract

Formación de usuarios-Difusión de recursos en el CSIC

En esta presentación se plantea la formación de usuarios cómo uno de los servicios de las bibliotecas del CSIC cuya finalidad es el aprovechamiento de los diferentes recursos de información disponibles : OPAC, bases de datos, colecciones impresas y colecciones digitales

Влияние фазовых модификаций кремнезема на фильтрационно-емкостные свойства пород-коллекторов на газовых месторождениях

Фазовые модификации кремнезема из аморфной фазы в кристаллическую вызывают изменение порового пространства и проницаемости пород-коллекторов газовых месторождений. Данный переход к кремнезема определяет разработку и поиск газовых месторождений.Phase modifications of silica from the amorphous phase in the crystalline process of changing the threshold space and permeability of rock reservoirs of gas fields. This transition to silica determines the development and search for gas deposits

C5aR1 Activation Drives Early IFN-gamma Production to Control ExperimentalToxoplasma gondiiInfection

Toxoplasma gondii (T. gondii) is a parasite infecting animals and humans. In intermediate hosts, such as humans or rodents, rapidly replicating tachyzoites drive vigorous innate and adaptive immune responses resulting in bradyzoites that survive within tissue cysts. Activation of the innate immune system is critical during the early phase of infection to limit pathogen growth and to instruct parasite-specific adaptive immunity. In rodents, dendritic cells (DCs) senseT. gondiithrough TLR11/12, leading to IL-12 production, which activates NK cells to produce IFN-gamma as an essential mechanism for early parasite control. Further, C3 can bind toT. gondiiresulting in limited complement activation. Here, we determined the role of C5a/C5aR1 axis activation for the early innate immune response in a mouse model of peritonealT. gondiiinfection. We found thatC5ar1(-/-)animals suffered from significantly higher weight loss, disease severity, mortality, and parasite burden in the brain than wild type control animals. Severe infection inC5ar1(-/-)mice was associated with diminished serum concentrations of IL-12, IL-27, and IFN-gamma. Importantly, the serum levels of pro-inflammatory cytokines, including IL-1 alpha, IL-6, and TNF-alpha, as well as several CXC and CC chemokines, were decreased in comparison to wt animals, whereas anti-inflammatory IL-10 was elevated. The defect in IFN-gamma production was associated with diminishedIfngmRNA expression in the spleen and the brain, reduced frequency of IFN-gamma+NK cells in the spleen, and decreasedNos2expression in the brain ofC5ar1(-/-)mice. Mechanistically, DCs from the spleen ofC5ar1(-/-)mice produced significantly less IL-12 in response to soluble tachyzoite antigen (STAg) stimulationin vivoandin vitro. Our findings suggest a model in which the C5a/C5aR1 axis promotes IL-12 induction in splenic DCs that is critical for IFN-gamma production from NK cells and subsequent iNOS expression in the brain as a critical mechanism to control acuteT. gondiiinfection